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  1. Content type: Review

    An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several commo...

    Authors: Augustin Luna, Mirit I Aladjem and Kurt W Kohn

    Citation: Genome Integrity 2013 4:6

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  2. Content type: Review

    Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chem...

    Authors: Kaisa R Luoto, Ramya Kumareswaran and Robert G Bristow

    Citation: Genome Integrity 2013 4:5

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  3. Content type: Research

    Shortening of telomeres, which are essential for maintenance of genomic integrity, is a mechanism commonly associated with the aging process. Here we ascertained whether changes in telomere lengths or telomera...

    Authors: Klara Sputova, James C Garbe, Fanny A Pelissier, Eric Chang, Martha R Stampfer and Mark A LaBarge

    Citation: Genome Integrity 2013 4:4

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  4. Content type: Research

    Histone post-translational modifications are critical determinants of chromatin structure and function, impacting multiple biological processes including DNA transcription, replication, and repair. The post-tr...

    Authors: Nobuo Horikoshi, Pankaj Kumar, Girdhar G Sharma, Min Chen, Clayton R Hunt, Kenneth Westover, Shantanu Chowdhury and Tej K Pandita

    Citation: Genome Integrity 2013 4:3

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  5. Content type: Research

    Telomeres, the physical ends of chromosomes, play an important role in preserving genomic integrity. This protection is supported by telomere binding proteins collectively known as the shelterin complex. The s...

    Authors: Hemad Yasaei, Yaghoub Gozaly-Chianea and Predrag Slijepcevic

    Citation: Genome Integrity 2013 4:2

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  6. Content type: Commentary

    Interstrand crosslinks covalently link complementary DNA strands, block replication and transcription, and can trigger cell death. In eukaryotic systems several pathways, including the Fanconi Anemia pathway, ...

    Authors: Danielle L Daee and Kyungjae Myung

    Citation: Genome Integrity 2012 3:7

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  7. Content type: Research

    Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized ...

    Authors: Ivana Joksic, Dragana Vujic, Marija Guc-Scekic, Andreja Leskovac, Sandra Petrovic, Maryam Ojani, Juan P Trujillo, Jordi Surralles, Maja Zivkovic, Aleksandra Stankovic, Predrag Slijepcevic and Gordana Joksic

    Citation: Genome Integrity 2012 3:6

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  8. Content type: Research

    Cancer cells can employ telomerase or the alternative lengthening of telomeres (ALT) pathway for telomere maintenance. Cancer cells that use the ALT pathway exhibit distinct phenotypes such as heterogeneous te...

    Authors: Jacklyn W Y Yong, Xiujun Yeo, Md Matiullah Khan, Martin B Lee and M Prakash Hande

    Citation: Genome Integrity 2012 3:5

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  9. Content type: Research

    Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterize...

    Authors: Alexander Facista, Huy Nguyen, Cristy Lewis, Anil R Prasad, Lois Ramsey, Beryl Zaitlin, Valentine Nfonsam, Robert S Krouse, Harris Bernstein, Claire M Payne, Stephen Stern, Nicole Oatman, Bhaskar Banerjee and Carol Bernstein

    Citation: Genome Integrity 2012 3:3

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  10. Content type: Research

    Investigating the cellular and molecular signatures in eukaryotic cells following exposure to nanoparticles will further our understanding on the mechanisms mediating nanoparticle induced effects. This study i...

    Authors: PV AshaRani, Swaminathan Sethu, Hui Kheng Lim, Ganapathy Balaji, Suresh Valiyaveettil and M Prakash Hande

    Citation: Genome Integrity 2012 3:2

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  11. Content type: Research

    The quantification of radiation-induced foci (RIF) to investigate the induction and subsequent repair of DNA double strands breaks is now commonplace. Over the last decade systems specific for the automatic qu...

    Authors: Andrew McVean, Simon Kent, Alexei Bakanov, Tom Hobbs and Rhona Anderson

    Citation: Genome Integrity 2012 3:1

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  12. Content type: Research

    Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging, neurodegenerative diseases, and cancer. Therefore, there exists great interest to dev...

    Authors: Tyson A Clark, Kristi E Spittle, Stephen W Turner and Jonas Korlach

    Citation: Genome Integrity 2011 2:10

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  13. Content type: Research

    Recent studies suggest that BRCA2 affects telomere maintenance. Interestingly, anti cancer treatments that involve BRCA2 and telomerase individually are currently being explored. In the light of the above rece...

    Authors: Ester Sapir, Yaghoub Gozaly-Chianea, Suliman Al-Wahiby, Sainu Ravindran, Hemad Yasaei and Predrag Slijepcevic

    Citation: Genome Integrity 2011 2:9

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  14. Content type: Research

    Genome instability is associated with human cancers and chromosome breakage syndromes, including Bloom's syndrome, caused by inactivation of BLM helicase. Numerous mutations that lead to genome instability are...

    Authors: Lillian Doerfler, Lorena Harris, Emilie Viebranz and Kristina H Schmidt

    Citation: Genome Integrity 2011 2:8

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  15. Content type: Short Report

    Transgenic cattle carrying multiple genomic modifications have been produced by serial rounds of somatic cell chromatin transfer (cloning) of sequentially genetically targeted somatic cells. However, cloning e...

    Authors: George E Liu, Yali Hou, James M Robl, Yoshimi Kuroiwa and Zhongde Wang

    Citation: Genome Integrity 2011 2:6

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  16. Content type: Research

    In mammalian cells gene amplification is a common manifestation of genome instability promoted by DNA double-strand breaks (DSBs). The repair of DSBs mainly occurs through two mechanisms: non-homologous end-jo...

    Authors: Aurora Ruiz-Herrera, Alexandra Smirnova, Lela Khouriauli, Solomon G Nergadze, Chiara Mondello and Elena Giulotto

    Citation: Genome Integrity 2011 2:5

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  17. Content type: Research

    Fanconi anemia (FA) is a rare autosomal recessive syndrome characterized by developmental abnormalities, progressive bone marrow failure, and predisposition to cancer. The key FA protein FANCD2 crosstalks with...

    Authors: Alex Lyakhovich, Maria Jose Ramirez, Andres Castellanos, Maria Castella, Amanda M Simons, Jeffrey D Parvin and Jordi Surralles

    Citation: Genome Integrity 2011 2:4

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  18. Content type: Review

    Radiation therapy is a widely used therapeutic approach for cancer. To improve the efficacy of radiotherapy there is an intense interest in combining this modality with two broad classes of compounds, radiosen...

    Authors: Li-Jeen Mah, Christian Orlowski, Katherine Ververis, Raja S Vasireddy, Assam El-Osta and Tom C Karagiannis

    Citation: Genome Integrity 2011 2:3

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  19. Content type: Research

    The Nucleotide Excision Repair (NER) pathway specialises in UV-induced DNA damage repair. Inherited defects in the NER can predispose individuals to Xeroderma Pigmentosum (XP). UV-induced DNA damage cannot acc...

    Authors: Kalpana Gopalakrishnan, Grace Kah Mun Low, Aloysius Poh Leong Ting, Prarthana Srikanth, Predrag Slijepcevic and M Prakash Hande

    Citation: Genome Integrity 2010 1:16

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  20. Content type: Review

    DNA double-strand breaks are among the most serious types of DNA damage and their signaling and repair is critical for all cells and organisms. The repair of both induced and programmed DNA breaks is fundament...

    Authors: Toshiyuki Bohgaki, Miyuki Bohgaki and Razqallah Hakem

    Citation: Genome Integrity 2010 1:15

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  21. Content type: Review

    Bloom Syndrome (BS) is an autosomal recessive disorder due to mutation in Bloom helicase (referred in literature either as BLM helicase or BLM). Patients with BS are predisposed to almost all forms of cancer. ...

    Authors: Shweta Tikoo and Sagar Sengupta

    Citation: Genome Integrity 2010 1:14

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  22. Content type: Research

    Proteins involved in the DNA damage response accumulate as microscopically-visible nuclear foci on the chromatin flanking DNA double-strand breaks (DSBs). As growth of ionizing radiation (IR)-induced foci ampl...

    Authors: Aya Ishikawa, Motohiro Yamauchi, Keiji Suzuki and Shunichi Yamashita

    Citation: Genome Integrity 2010 1:10

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  23. Content type: Research

    Adjuvant radiotherapy for cancer can result in severe adverse side effects for normal tissues. In this respect, individuals with anomalies of the ATM (ataxia telangiectasia) protein/gene are of particular inte...

    Authors: Zhiming Fang, Sergei Kozlov, Michael J McKay, Rick Woods, Geoff Birrell, Carl N Sprung, Dédée F Murrell, Kiran Wangoo, Linda Teng, John H Kearsley, Martin F Lavin, Peter H Graham and Raymond A Clarke

    Citation: Genome Integrity 2010 1:9

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  24. Content type: Research

    It has been shown by a number of authors that the radiosensitivity of peripheral blood mononuclear cells (PBMC) is higher in cancer patients compared to healthy donors, which is interpreted as a sign of genomi...

    Authors: Halina Lisowska, Marta Deperas-Kaminska, Siamak Haghdoost, Ingela Parmryd and Andrzej Wojcik

    Citation: Genome Integrity 2010 1:8

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  25. Content type: Research

    DNA double-strand breaks (DSBs) caused by ionizing radiation or by the stalling of DNA replication forks are among the most deleterious forms of DNA damage. The ability of cells to recognize and repair DSBs re...

    Authors: Helena Mistry, Laura Tamblyn, Hussein Butt, Daniel Sisgoreo, Aileen Gracias, Meghan Larin, Kalpana Gopalakrishnan, Manoor Prakash Hande and John Peter McPherson

    Citation: Genome Integrity 2010 1:7

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  26. Content type: Research

    Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA. The reactivation of telomerase activity by aberrant upregulation/expression of its catalytic subunit hTERT is a major pathway in human tumo...

    Authors: Satoshi Abe, Hiromi Tanaka, Tomomi Notsu, Shin-ichi Horike, Chikako Fujisaki, Dong-Lai Qi, Takahito Ohhira, David Gilley, Mitsuo Oshimura and Hiroyuki Kugoh

    Citation: Genome Integrity 2010 1:6

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  27. Content type: Research

    The telomerase enzyme is a viable target for anti-cancer therapy given the innate differences in telomerase activity between tumour cells and normal somatic cells. However, the time lag between telomerase inhi...

    Authors: Resham L Gurung, Lakshmidevi Balakrishnan, Rabindra N Bhattacharjee, Jayapal Manikandan, Srividya Swaminathan and M Prakash Hande

    Citation: Genome Integrity 2010 1:5

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  28. Content type: Research

    DNA double strand breaks induced by DNA damaging agents, such ionizing radiation, are repaired by multiple DNA repair pathways including non-homologous end-joining (NHEJ) repair and homologous recombination (H...

    Authors: Keiji Suzuki, Maiko Takahashi, Yasuyoshi Oka, Motohiro Yamauchi, Masatoshi Suzuki and Shunichi Yamashita

    Citation: Genome Integrity 2010 1:4

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  29. Content type: Research

    Repair of DNA double strand breaks by non-homologous end joining (NHEJ) requires several proteins including Ku, DNA-PKcs, Artemis, XRCC4, Ligase IV and XLF. Two of these proteins, namely Ku and DNA-PKcs, are a...

    Authors: Hemad Yasaei and Predrag Slijepcevic

    Citation: Genome Integrity 2010 1:3

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