Figure 2
Kinetic effects of products of alkylation DNA damage in SMRT sequencing. Normalized IPD ratios (top panel) and PW ratios (bottom panel) between the modified and unmodified DNA templates are shown for (a) O6 mG, (b) 1 mA, and (c) O4 mT, with the DNA template sequence as the x axis. The two template positions carrying the base modifications are highlighted with red bars and underlined sequence labels.