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  1. Review

    SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism

    An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several commo...

    Augustin Luna, Mirit I Aladjem and Kurt W Kohn

    Genome Integrity 2013 4:6

    Published on: 20 December 2013

  2. Review

    Tumor hypoxia as a driving force in genetic instability

    Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chem...

    Kaisa R Luoto, Ramya Kumareswaran and Robert G Bristow

    Genome Integrity 2013 4:5

    Published on: 24 October 2013

  3. Research

    Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length

    Shortening of telomeres, which are essential for maintenance of genomic integrity, is a mechanism commonly associated with the aging process. Here we ascertained whether changes in telomere lengths or telomera...

    Klara Sputova, James C Garbe, Fanny A Pelissier, Eric Chang, Martha R Stampfer and Mark A LaBarge

    Genome Integrity 2013 4:4

    Published on: 29 May 2013

  4. Research

    Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression

    Histone post-translational modifications are critical determinants of chromatin structure and function, impacting multiple biological processes including DNA transcription, replication, and repair. The post-tr...

    Nobuo Horikoshi, Pankaj Kumar, Girdhar G Sharma, Min Chen, Clayton R Hunt, Kenneth Westover, Shantanu Chowdhury and Tej K Pandita

    Genome Integrity 2013 4:3

    Published on: 12 April 2013

  5. Commentary

    Fanconi-like crosslink repair in yeast

    Interstrand crosslinks covalently link complementary DNA strands, block replication and transcription, and can trigger cell death. In eukaryotic systems several pathways, including the Fanconi Anemia pathway, ...

    Danielle L Daee and Kyungjae Myung

    Genome Integrity 2012 3:7

    Published on: 12 October 2012

  6. Research

    Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients

    Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized ...

    Ivana Joksic, Dragana Vujic, Marija Guc-Scekic, Andreja Leskovac, Sandra Petrovic, Maryam Ojani, Juan P Trujillo, Jordi Surralles, Maja Zivkovic, Aleksandra Stankovic, Predrag Slijepcevic and Gordana Joksic

    Genome Integrity 2012 3:6

    Published on: 14 September 2012

  7. Research

    Stable expression of promyelocytic leukaemia (PML) protein in telomerase positive MCF7 cells results in alternative lengthening of telomeres phenotype

    Cancer cells can employ telomerase or the alternative lengthening of telomeres (ALT) pathway for telomere maintenance. Cancer cells that use the ALT pathway exhibit distinct phenotypes such as heterogeneous te...

    Jacklyn W Y Yong, Xiujun Yeo, Md Matiullah Khan, Martin B Lee and M Prakash Hande

    Genome Integrity 2012 3:5

    Published on: 27 August 2012

  8. Research

    Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer

    Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterize...

    Alexander Facista, Huy Nguyen, Cristy Lewis, Anil R Prasad, Lois Ramsey, Beryl Zaitlin, Valentine Nfonsam, Robert S Krouse, Harris Bernstein, Claire M Payne, Stephen Stern, Nicole Oatman, Bhaskar Banerjee and Carol Bernstein

    Genome Integrity 2012 3:3

    Published on: 11 April 2012

  9. Research

    Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

    Investigating the cellular and molecular signatures in eukaryotic cells following exposure to nanoparticles will further our understanding on the mechanisms mediating nanoparticle induced effects. This study i...

    PV AshaRani, Swaminathan Sethu, Hui Kheng Lim, Ganapathy Balaji, Suresh Valiyaveettil and M Prakash Hande

    Genome Integrity 2012 3:2

    Published on: 10 February 2012

  10. Research

    Direct Detection and Sequencing of Damaged DNA Bases

    Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging, neurodegenerative diseases, and cancer. Therefore, there exists great interest to dev...

    Tyson A Clark, Kristi E Spittle, Stephen W Turner and Jonas Korlach

    Genome Integrity 2011 2:10

    Published on: 20 December 2011

  11. Research

    Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells

    Recent studies suggest that BRCA2 affects telomere maintenance. Interestingly, anti cancer treatments that involve BRCA2 and telomerase individually are currently being explored. In the light of the above rece...

    Ester Sapir, Yaghoub Gozaly-Chianea, Suliman Al-Wahiby, Sainu Ravindran, Hemad Yasaei and Predrag Slijepcevic

    Genome Integrity 2011 2:9

    Published on: 9 December 2011

  12. Research

    Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

    Genome instability is associated with human cancers and chromosome breakage syndromes, including Bloom's syndrome, caused by inactivation of BLM helicase. Numerous mutations that lead to genome instability are...

    Lillian Doerfler, Lorena Harris, Emilie Viebranz and Kristina H Schmidt

    Genome Integrity 2011 2:8

    Published on: 31 October 2011

  13. Short Report

    Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning

    Transgenic cattle carrying multiple genomic modifications have been produced by serial rounds of somatic cell chromatin transfer (cloning) of sequentially genetically targeted somatic cells. However, cloning e...

    George E Liu, Yali Hou, James M Robl, Yoshimi Kuroiwa and Zhongde Wang

    Genome Integrity 2011 2:6

    Published on: 23 May 2011

  14. Research

    Gene amplification in human cells knocked down for RAD54

    In mammalian cells gene amplification is a common manifestation of genome instability promoted by DNA double-strand breaks (DSBs). The repair of DSBs mainly occurs through two mechanisms: non-homologous end-jo...

    Aurora Ruiz-Herrera, Alexandra Smirnova, Lela Khouriauli, Solomon G Nergadze, Chiara Mondello and Elena Giulotto

    Genome Integrity 2011 2:5

    Published on: 18 March 2011

  15. Research

    Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner

    Fanconi anemia (FA) is a rare autosomal recessive syndrome characterized by developmental abnormalities, progressive bone marrow failure, and predisposition to cancer. The key FA protein FANCD2 crosstalks with...

    Alex Lyakhovich, Maria Jose Ramirez, Andres Castellanos, Maria Castella, Amanda M Simons, Jeffrey D Parvin and Jordi Surralles

    Genome Integrity 2011 2:4

    Published on: 12 February 2011

  16. Review

    Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks

    Radiation therapy is a widely used therapeutic approach for cancer. To improve the efficacy of radiotherapy there is an intense interest in combining this modality with two broad classes of compounds, radiosen...

    Li-Jeen Mah, Christian Orlowski, Katherine Ververis, Raja S Vasireddy, Assam El-Osta and Tom C Karagiannis

    Genome Integrity 2011 2:3

    Published on: 25 January 2011

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