Genome Integrity

Table 2 Analysis of total telomeric fusions in the primary human fibroblast cells

From: Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition

		Frequency (event/cell)
Cell Line	Metaphase cells analyzed	Total telomeric fusions	Breaks/Fragments
GM08399 (WT)
Untreated (DMSO)	111	0.018 ± 0.015	0.000 ± 0.000
Treated (DNA-PKcsi)	150	0.087 ± 0.028	0.067 ± 0.007
CJ179 (Art)
Untreated (DMSO)	194	0.067 ± 0.026	0.015 ± 0.009
Treated (DNA-PKcsi)	182	0.203 ± 0.047	0.104 ± 0.005
F01-240 (Art)
Untreated (DMSO)	174	0.081 ± 0.026	0.017 ± 0.012
Treated (DNA-PKcsi)	140	0.136 ± 0.021	0.157 ± 0.062

Frequencies of break/fragments in two Artemis defective human primary cells and normal human primary counterpart induced with DNA-PKcs inhibitor from two independent experiments are shown. Numbers indicated are mean ± s.d.

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