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Table 2 Analysis of total telomeric fusions in the primary human fibroblast cells

From: Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition

   Frequency (event/cell)
Cell Line Metaphase cells analyzed Total telomeric fusions Breaks/Fragments
GM08399 (WT)    
Untreated (DMSO) 111 0.018 ± 0.015 0.000 ± 0.000
Treated (DNA-PKcsi) 150 0.087 ± 0.028 0.067 ± 0.007
CJ179 (Art)    
Untreated (DMSO) 194 0.067 ± 0.026 0.015 ± 0.009
Treated (DNA-PKcsi) 182 0.203 ± 0.047 0.104 ± 0.005
F01-240 (Art)    
Untreated (DMSO) 174 0.081 ± 0.026 0.017 ± 0.012
Treated (DNA-PKcsi) 140 0.136 ± 0.021 0.157 ± 0.062
  1. Frequencies of break/fragments in two Artemis defective human primary cells and normal human primary counterpart induced with DNA-PKcs inhibitor from two independent experiments are shown. Numbers indicated are mean ± s.d.