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Table 1 Telo-FISH analysis of two mouse cell lines treated with inhibitor of DNA-PKcs

From: Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition

 

Frequency (event/cell)

Cell Line

Metaphases Scored

RB fusion

Telomeric Fusions

Breaks/Fragments

LY-R

    

Untreated (DMSO)

213

0.037b ± 0.012

0.075b ± 0.021

0.056

Treated (DNA-PKcsi)

201

0.088a ± 0.048

0.279a ± 0.011

0.277

LY-S

    

Untreated (DMSO)

189

0.159b ± 0.025

0.126b ± 0.003

0.140

Treated (DNA-PKcsi)

200

0.249a ± 0.046

0.410a ± 0.027

0.212

  1. Frequency of Robertsonian fusion, end-to-end telomeric fusions and DNA-DSB/fragments were recorded from two independent experiments in the LY-R and LY-S cell lines. The inhibition was induced for 24 -hour period before metaphase preparation. DMSO was used as control treatment. In each experiment at least 100 metaphases were scored (except in LY-S untreated). S.D. was used as measure of dispersion from the mean.
  2. a The difference in mean event/cell between untreated and treated cell lines are significant (p < 0.05).
  3. b The difference in mean event/cell between untreated cell lines are significant (p < 0.0001).
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Genome Integrity

ISSN: 2041-9414