Sequential tissue sections with discordant expression of Pms2, Ercc1 and Xpf. These crypts are from the biopsy of a 71 year old female patient who had a 1 cm adenocarcinoma. While Pms2 and Xpf have reduced expression in this tissue area, Ercc1 has high expression. In this mucosal area, one crypt is apparently fissioning into 3 crypts. Images taken at 200×.