Figure 4

Sequential tissue sections with all crypts having reduced "body" expression of Pms2 (A), Ercc1 (B) and Xpf (C). These crypts are from a histologically normal area of a colon resection of a male patient who had an adenocarcinoma in the sigmoid colon (same tissue as in Figure 3). There is high expression of Ercc1 at the neck and surface of the crypts (B). There is also some expression of Xpf at the neck of each crypt but not in the clonic lumen in this area of tissue (C). For Pms2 (A), there is reduced expression in the body, the neck and surface for all epithelial cells. Images taken at 200×.