Figure 2

Sequential sections of the same crypt with high expression of Pms2 (A), Ercc1 (B) and Xpf (C). This crypt, from the biopsy of a 58 year old male patient who never had colonic neoplasia, shows high expression (brown) in absorptive cell nuclei throughout most of the crypt for each of the proteins. Note that Pms2 and Xpf expression (in panels A and C) are each reduced or absent in the nuclei of cells at the top of the crypt and within the surface of the colonic lumen between crypts. Images taken at 200×.