Skip to main content

Table 5 Summary of major up regulated genes and corresponding pathways involved in Ag-np exposure

From: Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

Gene (IMR-90) Pathways Genes (U251) Pathways
Jun oncogene
(JUN)
a) Mitogenic Pathway:
b) Wnt Pathway
c) PI3 Kinase/AKT Pathway
d) Calcium and Protein Kinase C Pathway
Jun oncogene (JUN) a) Mitogenic Pathway:
b) Wnt Pathway
c) PI3 Kinase/AKT Pathway
d) Calcium and Protein Kinase C Pathway
Bone morphogenetic protein 2 (BMP2) Hedgehog Pathway Fibronectin 1 (FN1) PI3 Kinase/AKT Pathway
Interleukin 8 (IL8) NFκB Pathway Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) (NFκB1) NFκB Pathway:
Colony stimulating factor 2 (granulocyte-macrophage, CSF2) a) Calcium and Protein Kinase C Pathway
b) LDL Pathway
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha(NFκBIA) NFκB Pathway
Transferrin receptor (p90, CD71), (TFRC) Calcium and Protein Kinase C Pathway Transferrin receptor (p90, CD71), (TFRC) Calcium and Protein Kinase C Pathway
   Growth arrest and DNA-damage-inducible, alpha (GADD45A) p53 Pathway
   CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) Insulin Pathway