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Table 5 Summary of major up regulated genes and corresponding pathways involved in Ag-np exposure

From: Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

Gene (IMR-90)

Pathways

Genes (U251)

Pathways

Jun oncogene

(JUN)

a) Mitogenic Pathway:

b) Wnt Pathway

c) PI3 Kinase/AKT Pathway

d) Calcium and Protein Kinase C Pathway

Jun oncogene (JUN)

a) Mitogenic Pathway:

b) Wnt Pathway

c) PI3 Kinase/AKT Pathway

d) Calcium and Protein Kinase C Pathway

Bone morphogenetic protein 2 (BMP2)

Hedgehog Pathway

Fibronectin 1 (FN1)

PI3 Kinase/AKT Pathway

Interleukin 8 (IL8)

NFκB Pathway

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) (NFκB1)

NFκB Pathway:

Colony stimulating factor 2 (granulocyte-macrophage, CSF2)

a) Calcium and Protein Kinase C Pathway

b) LDL Pathway

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha(NFκBIA)

NFκB Pathway

Transferrin receptor (p90, CD71), (TFRC)

Calcium and Protein Kinase C Pathway

Transferrin receptor (p90, CD71), (TFRC)

Calcium and Protein Kinase C Pathway

  

Growth arrest and DNA-damage-inducible, alpha (GADD45A)

p53 Pathway

  

CCAAT/enhancer binding protein (C/EBP), beta (CEBPB)

Insulin Pathway