Genome Integrity

Table 1 Differentially expressed genes in cell cycle pathway.

From: Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

IMR 90			U251
Gene	Genbank ID	Fold change	Gene	Genbank ID	Fold change
CDC2	NM_001786	24.24	ANAPC2	NM_013366	0.33
CDKN3	NM_005192	-0.67	CDK5R2	NM_003936	4.93
PCNA	NM_182649	-0.58	RB1	NM_000321	0.65
SUM01	NM_003352	-0.67	BAX	NM_004324	0.96
UBE1	NM_003334	-0.69	CDKN3	NM_005192	-0.87
MCM2	NM_004526	-0.27	CCNE1	NM_001238	-0.55
BIRC5	NM_001168	-0.22	E2F1	NM_005225	-0.75
CCNH	NM_001239	-0.27	PCNA	NM_182649	-0.78
ANAPC4	NM_013367	-0.51	SUM01	NM_003352	-0.37
KPNA2	NM_002266	-0.37	UBE1	NM_003334	-0.61
CCNB1	NM_031966	-0.91	MCM7	NM_005916	-0.90
RGC32	NM_014059	-0.61	CCNG2	NM_004354	-0.34
CDC20	NM_001255	-0.59	CCNB1	NM_031966	-0.75
CCNE2	NM_057735	-0.40	PKMYT1	NM_182687	-0.34
GADD45A	NM_001924	-0.33	CKS1B	NM_001826	-0.77
RB1	NM_000321	-0.33	CDC16	NM_003903	-0.21
			MKI67	NM_002417	-0.78
			MAD2L2	NM_006341	-0.56

Gene expression changes in IMR 90 and U251cells following Ag-np exposure. All values are normalized against housekeeping genes. Fold change is calculated as treated/control - 1*. *Basal levels were normalised to 0.

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