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Figure 3 | Genome Integrity

Figure 3

From: Resolution of complex ends by non-homologous end joining - better to be lucky than good?

Figure 3

Joining by tolerance. The NHEJ core machinery can be associated with an XLF-XRCC4 filament that may stabilize aligned complex end structures (i) sufficiently to support transfer of the adenylate from the ligase to 5 phosphate terminus (ii), possibly through to complete ligation (iii). If ligation aborts, the 5 adenylated (AMP) intermediate can be removed by Aprataxin (APTX) (iv). DNA-PKcs-directed phosphorylation of XLF and XRCC4 can disrupt the XLF-XRCC4 filament (v) to allow processing factors access to the DNA to remove the obstruction.

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