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Table 5 Effect of C-terminal deletions of Exo1 on the spontaneous mutation rate at the CAN1 locus.

From: Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

Relevant genotype CAN1
(Canr × 10-7)
95% CIa
(Canr × 10-7)
Increase over wildtype
wildtype 3.27 2.50 - 5.82 1
exo1Δ 11.47 10.10 - 28.52 3.5
exo1-ΔC100.myc 3.64 2.92 - 4.70 1.1
exo1-ΔC200.myc 5.31 3.90 - 5.90 1.6
exo1-ΔC260.myc 3.89 2.89 - 5.92 1.2
exo1-ΔC280.myc 8.37 6.94 - 16.18 2.6
exo1-ΔC300.myc 10.72 8.55 - 19.88 3.3
exo1-ΔC400.myc 13.16 9.06 - 18.19 4.0
  1. a 95% confidence intervals (CI) for median Canr rates were calculated according to Nair [80].