Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

Table 5 Effect of C-terminal deletions of Exo1 on the spontaneous mutation rate at the CAN1 locus.

Relevant genotype	CAN1 (Can^r × 10^-7)	95% CI^a (Can^r × 10^-7)	Increase over wildtype
wildtype	3.27	2.50 - 5.82	1
exo1Δ	11.47	10.10 - 28.52	3.5
exo1-ΔC100.myc	3.64	2.92 - 4.70	1.1
exo1-ΔC200.myc	5.31	3.90 - 5.90	1.6
exo1-ΔC260.myc	3.89	2.89 - 5.92	1.2
exo1-ΔC280.myc	8.37	6.94 - 16.18	2.6
exo1-ΔC300.myc	10.72	8.55 - 19.88	3.3
exo1-ΔC400.myc	13.16	9.06 - 18.19	4.0

^a 95% confidence intervals (CI) for median Can^r rates were calculated according to Nair [80].