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Table 4 Effect of exo1 mutations on the accumulation of GCRs in wildtype cells or cells lacking Sgs1 helicase.

From: Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

Relevant genotype GCR rate
(Canr 5-FOAr × 10-10)
95% CIa
(Canr 5-FOAr × 10-10)
sgs1Δ 89 57-177
exo1Δ 24 7-79
exo1Δ sgs1Δ 40484 31076-49848
EXO1.myc 5 4.4-5.3
exo1-ΔC100.myc 5 4-6
exo1-ΔC200.myc < 4 < 3.8-4.8
exo1-ΔC260.myc < 11 < 8-79
exo1-ΔC280.myc < 11 < 8-29
exo1-ΔC300.myc < 18 < 5-70
exo1-ΔC400.myc 13 5-41
sgs1Δ EXO1.myc 78 29-118
sgs1Δ exo1-ΔC100.myc 125 80-186
sgs1Δ exo1-ΔC200.myc 158 94-215
sgs1Δ exo1-ΔC260.myc 230 166-265
sgs1Δ exo1-ΔC280.myc 26840 22925-34036
sgs1Δ exo1-ΔC300.myc 31070 22871-33753
sgs1Δ exo1-ΔC400.myc 48190 39133-54471
  1. a 95% confidence intervals (CI) for median GCR rates were calculated according to Nair [80].