Genome Integrity

Table 4 Effect of exo1 mutations on the accumulation of GCRs in wildtype cells or cells lacking Sgs1 helicase.

From: Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

Relevant genotype	GCR rate (Can^r 5-FOA^r × 10^-10)	95% CI^a (Can^r 5-FOA^r × 10^-10)
sgs1Δ	89	57-177
exo1Δ	24	7-79
exo1Δ sgs1Δ	40484	31076-49848
EXO1.myc	5	4.4-5.3
exo1-ΔC100.myc	5	4-6
exo1-ΔC200.myc	< 4	< 3.8-4.8
exo1-ΔC260.myc	< 11	< 8-79
exo1-ΔC280.myc	< 11	< 8-29
exo1-ΔC300.myc	< 18	< 5-70
exo1-ΔC400.myc	13	5-41
sgs1Δ EXO1.myc	78	29-118
sgs1Δ exo1-ΔC100.myc	125	80-186
sgs1Δ exo1-ΔC200.myc	158	94-215
sgs1Δ exo1-ΔC260.myc	230	166-265
sgs1Δ exo1-ΔC280.myc	26840	22925-34036
sgs1Δ exo1-ΔC300.myc	31070	22871-33753
sgs1Δ exo1-ΔC400.myc	48190	39133-54471

^a 95% confidence intervals (CI) for median GCR rates were calculated according to Nair [80].

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