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Table 1 Clinical review for patients with adverse normal tissue reactions to radiotherapy

From: Low levels of ATM in breast cancer patients with clinical radiosensitivity

Patient Cancer Sex ATM% Age Reaction Clinical features
1 Prostate M 69 64 A RTOG4 - treatment terminated at 28 Gy
2 Prostate M 80 72 L RTOG3 - Proctitis
3 Prostate M 90 69 L RTOG3 - Proctitis
4 Prostate M 82 71 L RTOG3 - Proctitis
5 Prostate M 79 60 L RTOG3 - Cystitis
6 Prostate M 80 65 L RTOG3 - Proctitis
7 Cervix F 71 36 L RTOG3 - Urethral stricture
8 Cervix F 81 47 L RTOG3
9 Breast F 80 51 A RTOG3 - Moist desquamation
10*¥∞ Breast F 35 64 A&L RTOG4 - Familial Treatment terminated at 20 Gy
11*£¥ Breast F 45 54 A&L RTOG3 - Moist desquamation; skin atrophy/pigment
12 Breast F 82 57 L RTOG3 - Familial
13*∞£¥ Breast F 8 50 L RTOG4 - Familial, skin atrophy & fibrosis, necrosis
14 Breast F 77 41 L RTOG3 - Fibrosis (skin, subcutaneous tissue & breast)
15 Breast F 66 71 L RTOG4 - Familial
16*£ Breast F 30 77 L RTOG4
17 Breast F 64 47 L RTOG3
18 Breast F 88 58 L RTOG3
19 Breast F 69 62 L RTOG3
20 Breast F 66 70 L RTOG3
  1. ATM% ~ percentage of ATM protein compared with the highest ATM expresser; * ~ low level of ATM protein < 50% cut-off;
  2. A ~ severe acute reaction; L ~ severe late reaction; ¥ ~ Intermediate ICA count; ∞ ~ ATM mutation(s); £ ~ reduced ATM kinase activity.