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Table 1 Clinical review for patients with adverse normal tissue reactions to radiotherapy

From: Low levels of ATM in breast cancer patients with clinical radiosensitivity

Patient

Cancer

Sex

ATM%

Age

Reaction

Clinical features

1

Prostate

M

69

64

A

RTOG4 - treatment terminated at 28 Gy

2

Prostate

M

80

72

L

RTOG3 - Proctitis

3

Prostate

M

90

69

L

RTOG3 - Proctitis

4

Prostate

M

82

71

L

RTOG3 - Proctitis

5

Prostate

M

79

60

L

RTOG3 - Cystitis

6

Prostate

M

80

65

L

RTOG3 - Proctitis

7

Cervix

F

71

36

L

RTOG3 - Urethral stricture

8

Cervix

F

81

47

L

RTOG3

9

Breast

F

80

51

A

RTOG3 - Moist desquamation

10*¥∞

Breast

F

35

64

A&L

RTOG4 - Familial Treatment terminated at 20 Gy

11*£¥

Breast

F

45

54

A&L

RTOG3 - Moist desquamation; skin atrophy/pigment

12

Breast

F

82

57

L

RTOG3 - Familial

13*∞£¥

Breast

F

8

50

L

RTOG4 - Familial, skin atrophy & fibrosis, necrosis

14

Breast

F

77

41

L

RTOG3 - Fibrosis (skin, subcutaneous tissue & breast)

15

Breast

F

66

71

L

RTOG4 - Familial

16*£

Breast

F

30

77

L

RTOG4

17

Breast

F

64

47

L

RTOG3

18

Breast

F

88

58

L

RTOG3

19

Breast

F

69

62

L

RTOG3

20

Breast

F

66

70

L

RTOG3

  1. ATM% ~ percentage of ATM protein compared with the highest ATM expresser; * ~ low level of ATM protein < 50% cut-off;
  2. A ~ severe acute reaction; L ~ severe late reaction; ¥ ~ Intermediate ICA count; ∞ ~ ATM mutation(s); £ ~ reduced ATM kinase activity.