Figure 7
From: Low levels of ATM in breast cancer patients with clinical radiosensitivity
ATM kinase activity for LCLs 1 hour after an in vitro IR exposure of 5 Gy for breast cancer patients and controls. Obligate heterozygote ATH5ABR ~ the father of an A-T patient and his two siblings had high ICA counts of 2.18, 3.24, 2.50 & 2.48, respectively. The AT1ABR cell line, used here as a positive control, was originally derived from an A-T patient homozygous for a small (3 amino acid) in-frame deletion that destabilises the protein and which was reported previously with very low levels of mutant ATM protein [18].