Table 1 Increased chromosomal instability in UHRF1-depleted cellsa.
From: UHRF1 is a genome caretaker that facilitates the DNA damage response to γ-irradiation
Cell line | Chromosome Breaks | Chromatid Breaks | Fusions | Fragments | Total No. of aberrations |
|---|---|---|---|---|---|
Control shRNA-1 | 0 | 0 | 1 (0.02/cell) | 8 (0.16/cell) | 9 (0.18/cell) |
Control shRNA-2 | 0 | 0 | 2 (0.04/cell) | 12 (0.24/cell) | 14 (0.28/cell) |
Control shRNA-3 | 2 (0.04/cell) | 0 | 3 (0.06/cell) | 10 (0.2/cell) | 15 (0.3/cell) |
UHRF1 shRNA-1 | 1 (0.02/cell) | 0 | 5 (0.1/cell) | 47 (0.94/cell) | 53 (1.06/cell) |
UHRF1 shRNA-2 | 1 (0.02/cell) | 0 | 5 (0.1/cell) | 51 (1.02/cell) | 57 (1.14/cell) |
UHRF1 shRNA-3 | 9 (0.18/cell) | 1 (0.02/cell) | 1 (0.02/cell) | 54 (1.08/cell) | 65 (1.3/cell) |