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Table 1 Increased chromosomal instability in UHRF1-depleted cellsa.

From: UHRF1 is a genome caretaker that facilitates the DNA damage response to γ-irradiation

Cell line Chromosome Breaks Chromatid Breaks Fusions Fragments Total No. of aberrations
Control
shRNA-1
0 0 1
(0.02/cell)
8
(0.16/cell)
9
(0.18/cell)
Control
shRNA-2
0 0 2
(0.04/cell)
12
(0.24/cell)
14
(0.28/cell)
Control
shRNA-3
2
(0.04/cell)
0 3
(0.06/cell)
10
(0.2/cell)
15
(0.3/cell)
UHRF1
shRNA-1
1
(0.02/cell)
0 5
(0.1/cell)
47
(0.94/cell)
53
(1.06/cell)
UHRF1
shRNA-2
1
(0.02/cell)
0 5
(0.1/cell)
51
(1.02/cell)
57
(1.14/cell)
UHRF1
shRNA-3
9
(0.18/cell)
1
(0.02/cell)
1
(0.02/cell)
54
(1.08/cell)
65
(1.3/cell)
  1. aResults shown are number of chromosomal abnormalities detected in fifty metaphase spreads from three control shRNA and three UHRF1 shRNA (UHRF1-depleted) cell lines. The frequency of a given abnormality/metaphase is shown below in parentheses.