Skip to main content


Figure 3 | Genome Integrity

Figure 3

From: Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability

Figure 3

Inhibition of PARP in mTERC-/- led to greatest decrease in cell survival. Cell viability was analysed by crystal violet assay in mTERC+/+ and mTERC-/- following 24 hours of arsenite treatment, with and without 3-AB. Following exposure to arsenite, 3-AB treated mTERC-/- cells showed significant decrease in cell survival as compared to 3-AB treated mTERC+/+ cells (*p < 0.05). Data is represented as mean ± SE from three independent experiments.

Back to article page